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Omega-3 fatty acids upregulate BDNF expression through epigenetic modifications (e.g., histone acetylation) while inhibiting pro-inflammatory cytokines (39)

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Further, these findings contribute to the larger literature, by exploring the combined effects of ibuprofen and microplastics on Physella acuta , by addressing the knowledge gap of these pollutants and understanding multiple stressor exposure which is more relevant of real environmental conditions